Here's the thing. Melo is one of the best post-up players in the league. This is why iso-play for him works. Teams know this so they tend to double-team him a lot. However, I think a lot more PnR plays with Amare would help create offense more. If Melo can learn to play like Lebron and pass while playing "big", then I don't mind more iso-plays on him. But until he can "bigman-scoring PG" like Lebron, then I think more PnR for Amare needs to happen.
So, basically, not Amare as the first option, but Amare and Melo sharing the first option until Melo learns to play like Lebron